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张嘉玮,陈 英,邓伟丽,刘文静,徐凯月,万春晓.间歇性低压氧通过δ-阿片类受体表达保护心肌梗死大鼠心肌的研究[J].中国康复医学杂志,2020,(7):782~786
间歇性低压氧通过δ-阿片类受体表达保护心肌梗死大鼠心肌的研究    点此下载全文
张嘉玮  陈 英  邓伟丽  刘文静  徐凯月  万春晓
天津医科大学,天津市,300052
基金项目:天津市自然科学基金项目(18JCZDJC98900);天津市卫计委项目(16KJ122)
DOI:10.3969/j.issn.1001-1242.2020.07.004
摘要点击次数: 90
全文下载次数: 35
摘要:
      摘要 目的:研究间歇性低压氧 (intermittent hypobaric hypoxia,IHH) 能否提高δ-阿片类受体(delta-opioid receptor,DOR)的表达,对大鼠心肌梗死(myocardial infarction,MI)后心肌产生保护作用。 方法:24只SD大鼠随机分为假手术常氧干预组(Sham-Nor)、假手术低压氧干预组(Sham-IHH)、心梗常氧干预组(MI-Nor)和心梗低压氧干预组(MI-IHH)。心肌梗死造模1周后进行干预。4周后检测心脏重量指数、心肌纤维化程度、超声检测心脏功能及DOR蛋白表达。 结果:4周后,MI-IHH和MI-Nor组相比:心脏重量无显著性差异(P>0.05),MI-IHH组心肌纤维化显著减少(P<0.05)、左室收缩末内径(left ventricular end systolic diameter,LVESd)明显下降(P<0.01)、左室射血分数(left ventricular ejection fraction,LVEF)显著提高(P<0.001)、DOR显著增加(P<0.05),MI-Nor和MI-IHH组中DOR表达与LVEF呈正相关(P<0.05)。 结论:IHH能够通过提高大鼠DOR的表达产生心肌梗死后心肌保护作用。
关键词:间歇性低压氧  心肌梗死  左心室重构  δ-阿片类受体
Study on intermittent hypobaric hypoxia protection of myocardial infarction rats by δ-opioid receptor expression    Download Fulltext
Tianjin Medical University, Tianjin, 300052
Fund Project:
Abstract:
      Abstract Objective: To find out whether intermittent hypobaric hypoxia can increase the expression of delta-opioid receptor (DOR) and protect myocardium after myocardial infarction in rats. Method: Twenty-four rats were randomly divided into four groups: Sham-Nor group, Sham-IHH group, MI-Nor group and MI-IHH group. One week after left anterior descending coronary artery ligation, rats were exposed to different treatments. After 4 weeks’ treatment, the heart weight ratio, myocardial fibrosis area, cardiac function detected by echocardiography and delta-opioid receptor (DOR) expression were measured. Result: Four weeks later, there was no difference in heart weight ratio between MI-Nor group and MI-IHH group (P>0.05). Compared with MI-Nor group, myocardial fibrosis area decreased(P<0.05),left ventricular end systolic diameter (LVESd) decreased(P<0.01), left ventricular ejection fraction (LVEF) increased(P<0.001) and DOR expression elevated(P<0.05) in MI-IHH group. DOR expressions were positive relate to LVEF in MI-Nor group and MI-IHH group(P<0.05). Conclusion: IHH can protect myocardium after myocardial infarction by increasing DOR expression in rats.
Keywords:intermittent hypobaric hypoxia  myocardial infarction  left ventricular remodeling  delta-opioid receptor
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