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张保锋,刘 鹏,徐智勤,李伟峰.颞叶癫痫患者言语感知障碍的临床研究[J].中国康复医学杂志,2019,(7):783~788
颞叶癫痫患者言语感知障碍的临床研究    点此下载全文
张保锋  刘 鹏  徐智勤  李伟峰
中山大学附属第一医院康复医学科,广州,510080
基金项目:国家自然科学基金资助项目(81472154,81772439);广东省科技计划项目(2017A050501014);广州市科技计划项目(201604020115);广东省医学科学技术研究基金(A2017044)
DOI:
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摘要:
      摘要 目的:利用噪声环境下的言语听觉感知测试技术(hearing in noise test,HINT),研究颞叶癫痫(temporal lobe epilepsy, TLE)患者的言语感知能力并探讨其神经机制。 方法:选择30例TLE患者和30例年龄、性别匹配的正常对照作为研究对象,外周听力均正常,进行噪声环境下的言语感知能力测试,获得TLE组与正常对照组的信噪比阈值并进行对比分析。 结果:正常对照组的信噪比阈值明显低于TLE组(P<0.001),表明TLE患者在噪声环境下的言语感知能力出现显著下降。 结论:TLE患者虽然具有正常听力,但是噪声环境下理解言语的能力明显降低,严重影响了言语交流的效果。本研究首次证实TLE患者在言语感知方面存在缺陷,这可能与TLE导致中枢性听觉处理机制出现障碍有关。
关键词:颞叶癫痫  言语感知  中枢听觉处理障碍  噪声环境
A clinical study on deficits of speech perception in noise in patients with temporal lobe epilepsy    Download Fulltext
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080
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Abstract:
      Abstract Objective:To explore the behavioral performance of speech perception in noise in patients with temporal lobe epilepsy by means of hearing in noise test (HINT) and to discuss the possible underlying neural mechanisms. Method: Thirty patients with TLE and 30 age- and sex-matched healthy adult volunteers with normal peripheral hearing were recruited to participate in the present study. Each subject’s performance of speech perception in noise was evaluated using the HINT protocol. The threshold of signal-to-noise ratio (SNR) was obtained and then compared between the patients with TLE and healthy controls. Result:The SNR threshold of healthy controls was significantly lower than that of patients with TLE (P<0.001), indicating that patients with TLE were impaired in their ability of perceiving speech in noise. Conclusion: Although patients with TLE had normal peripheral hearing, their ability of understanding speech in noisy environment was impaired, which may lead to declined ability of speech communication. These findings provide the first evidence that patients with TLE are associated with deficits of speech perception in noise, which may be related to their central auditory processing disorders as a consequence of TLE.
Keywords:temporal lobe epilepsy  speech perception  central auditory processing disorder  noisy environment
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