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王加谋,刘彤鸥.运动结合中药复方对去势大鼠股骨生物力学影响的研究[J].中国康复医学杂志,2019,(1):11~15
运动结合中药复方对去势大鼠股骨生物力学影响的研究    点此下载全文
王加谋  刘彤鸥
武汉轻工大学医护学院附属武汉脑科医院,武汉,430023
基金项目:国家自然科学基金项目(81473465);湖北省自然科学基金项目(2017CFC832)
DOI:
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摘要:
      摘要 目的:探讨运动结合中药复方对去势大鼠骨生物力学改善的作用。 方法:取180日龄SPF级SD雌性大鼠100只,随机分为空白组、模型组、运动组、中药复方组、运动结合中药复方组,每组20只,造模术后常规饲养14天。之后除空白组外,各组分别灌胃治疗,模型组每天给予0.9%氯化钠注射液2ml灌胃;运动组每天给予0.9%氯化钠注射液2ml灌胃,并在高速平板跑台跑步20min,速度为5m/min;中药复方组每天给予中药复方溶液2ml灌胃;运动结合中药复方组每天给予中药复方溶液2ml灌胃,并在高速平板跑台跑步20min,速度为5m/min。干预治疗后12周后将大鼠戊巴比妥腹腔注射麻醉,处死,收集双侧股骨,剔净附着于股骨上的肌肉及结缔组织,分别进行三点弯曲试验、显微结构观察及骨小梁静态参数检测。 结果:与模型组比较,空白组、运动组、中药复方组、运动结合中药复方组在骨密度、股骨载荷、骨小梁静态参数检测指标均有明显差异(P<0.01或P<0.05)。 结论:运动结合中药复方具有改善去势大鼠骨生物力学指标,保护骨小梁结构的作用。
关键词:运动  中药复方  去势大鼠  骨质疏松  生物力学
Research on the effects of exercise combined with traditional Chinese medicine compound of castration on rat femur biomechanics    Download Fulltext
Wuhan Polytechnic University,Affiliated Brain Hospital of Wuhan,Wuhan,430023
Fund Project:
Abstract:
      Abstract Objective: To explore the rats bone biomechanics improvement action after exercise combined with traditional Chinese medicine compound of castration. Method: A total of 100 SPF SD female rats, aged 180 days, were randomly divided into blank group,model group,exercise,traditional Chinese medicine compound,sports combined with traditional Chinese medicine compound group, 20 in each group. Followed conventional breeding 14 days after surgery. 2ml 0.9% sodium chloride was filled to stomach daily for model group and exercise group. 2ml traditional Chinese medicine compound solution was filled to the stomach daily for the traditional Chinese medicine compound and sports combined with traditional Chinese medicine compound group. Besides, the rats were forced to running on flat treadmill 20 minutes daily at speed of 5m/min for exercise group and sports combined with traditional Chinese medicine compound group. After 12 weeks treatment, bilateral femur were collected, attached muscle and connective tissue were took out. Then three-point bending test, microstructure observation, and static parameters of bone trabecula test were completed. Result: BMD, maximal load of femur, and static parameters of bone trabecula test for model group, blank group, exercise group, Chinese medicine compound group, exercise combined with traditional Chinese medicine compound group all have obvious difference from the model group (P<0.01 or P<0.05). Conclusion: Exercise combined with traditional Chinese medicine compound is beneficial for treatment of osteoporosis in castrated rats.
Keywords:exercise  traditional Chinese medicine compound  castrated rats  osteoporosis  biomechanics
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