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杨 青,胡瑞萍,吴军发,杜小霞,朱玉连,汤昕未,范顺娟,田 闪,吴 毅.持续短阵脉冲刺激抑制一侧初级运动皮层后脑功能连接的变化[J].中国康复医学杂志,2018,(12):1394~1398
持续短阵脉冲刺激抑制一侧初级运动皮层后脑功能连接的变化    点此下载全文
杨 青  胡瑞萍  吴军发  杜小霞  朱玉连  汤昕未  范顺娟  田 闪  吴 毅
复旦大学附属华山医院康复医学科,上海市乌鲁木齐中路12号,200040
基金项目:上海市科学技术委员会资助项目(16411955400);上海市卫计委重要薄弱学科建设资助项目(2015ZB0401);上海市科学技术委员会资助项目(17411953900)
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摘要:
      摘要 目的:利用静息态功能磁共振成像技术,分析健康被试者一侧初级运动皮层经持续短阵脉冲刺激抑制后与全脑其他灰质区域的功能连接变化。 方法:采用持续短阵脉冲刺激(cTBS)对21例健康被试者的右侧初级运动皮层(M1区)进行抑制。在cTBS干预前和干预后即刻采集静息态功能磁共振数据,以右侧M1区受抑制最明显的区域作为种子点,与全脑其他灰质区域进行功能连接分析,比较右侧M1区种子点在cTBS干预前后与全脑其他区域功能连接的变化。 结果:右侧M1区种子点在cTBS干预前与大脑广泛区域存在较强的功能连接,在cTBS干预后功能连接范围缩小、连接强度减弱,以右侧扣带回中部和左侧中央后回减弱最为明显,具有显著性意义(单个体素P<0.001, GRF校正P<0.05)。 结论:健康被试者一侧运动皮层受到抑制后,与全脑灰质功能连接普遍减弱,尤以与同侧扣带回中部及对侧中央后回的功能连接减弱明显。
关键词:初级运动皮层  功能连接  持续短阵脉冲刺激
The change of the functional connectivity between the primary motor cortex and other areas of the whole brain gray matter after a session of continuous theta burst stimulation    Download Fulltext
Dept. of Rehabilitation Medicine, Huashan Hospital, Fudan University,Shanghai,200040
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Abstract:
      Abstract Objective:To examine the change of the functional connectivity between the primary motor cortex and other areas of the whole brain gray matter in healthy subjects after a session of inhibitory continuous theta burst stimulation. Method:Twenty-one healthy adult subjects were enrolled and received a session of inhibitory cTBS on the right primary motor cortex (M1). The resting-state functional MRI data of each subject was collected before and immediately after the cTBS session. The peak of the inhibited M1 cortex was chosen as the seed and its functional connectivity with other areas of the whole brain gray matter was analyzed (one sample t test, individual P<0.001,extent threshold P<0.05,GRF corrected) and compared between the two time points on voxel level (paired two sample t test, individual P<0.001, extent threshold P<0.05, GRF corrected) in all subjects. Result:Significant functional connectivity was found between the right M1 seed and widespread brain areas before, and less areas after, the cTBS intervention, in the whole brain, as revealed by one sample t test. The functional connectivity with the middle part of the right cingulate gyrus and the left postcentral gyrus showed the most significant weakness after the cTBS intervention (paired two sample t test, individual P<0.001, extent threshold P<0.05, GRF corrected). Conclusion:After the functional activity of the unilateral primary motor cortex was inhibited in healthy subjects, its functional connectivity with other areas in the whole brain also became weaker, especially with the ipsilateral middle cingulate gyrus and contralateral postcentral gyrus.
Keywords:primary motor cortex  functional connectivity  continuous theta-burst stimulation
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