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孙瑞芳,温红梅,曾 妍,李 超,孙 巨,张婵娟,曾佩珊,邹淑怡.跑笼训练与技巧性取食训练对脑梗死恢复期大鼠认知功能的影响[J].中国康复医学杂志,2018,(4):392~396
跑笼训练与技巧性取食训练对脑梗死恢复期大鼠认知功能的影响    点此下载全文
孙瑞芳  温红梅  曾 妍  李 超  孙 巨  张婵娟  曾佩珊  邹淑怡
中山大学附属第三医院康复科,广州,510630
基金项目:国家自然科学基金面上项目(81472156;81672259)
DOI:
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摘要:
      摘要 目的:比较脑梗死恢复期进行跑笼训练与技巧性取食训练对短暂性大脑中动脉闭塞(tMCAO)大鼠认知功能的影响。 方法:50只雄性SD大鼠经利手筛选及技巧性取食预训练后,根据tMCAO术后神经功能评分将大鼠分为四组:技巧性取食组(n=7)、跑笼组(n=8)、对照组(n=6)、假手术组(n=6),于术后第1、14、28、42、56天进行改良神经功能缺损程度评分(mNSS),于术后第56天进行Morris水迷宫实验。 结果:从第28天起技巧性取食组与跑笼组的mNSS均低于对照组(P<0.001),且技巧性取食组低于跑笼组(P<0.05)。水迷宫实验第1天、第2天和第4天跑笼组和对照组平均游泳路径长度较假手术组长(P<0.05),第1天和第4天技巧性取食组的平均游泳路径长度较跑笼组和对照组短(P<0.05);tMCAO各组穿越平台次数较假手术组少(P<0.05),技巧性取食组及跑笼组穿越平台次数较对照组多(P<0.05),且技巧性取食组较跑笼组多(P<0.05)。 结论:运动训练能够改善脑梗死恢复期大鼠的认知功能,且技巧性取食训练比跑笼训练效果更佳。
关键词:运动训练  短暂性大脑中动脉闭塞  恢复期  认知功能
Effects of running wheel exercise and skilled reaching training on the cognitive function in rats with transient middle cerebral artery occlusion at the recovery stage    Download Fulltext
Dept. of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630
Fund Project:
Abstract:
      Abstract Objective: To compare effects of running wheel exercise and skilled reaching training on the cognitive function in rats with middle cerebral artery occlusion (tMCAO) at the recovery stage. Method: Fifty adult male Sprague-Dawley rats after pre-training and handedness filtering were divided into four groups: skilled reaching group (n=7), running wheel group (n=8), control group (n=6) and sham group (n=6) were included in the final behavioral study according to Bederson score. Each group was assessed with mNSS on day 1, 14, 28, 42, 56 and Morris water maze test was carried out on day 56 after operation. Result: The mNSS was higher in control group than exercise groups(P<0.001) and running wheel group's scores were higher than skilled reaching group(P<0.05) from day 28. The swimming distance at the first, the second and the fourth day of water maze test were longer in the control group and the running wheel group as compared with that in the sham group(P<0.05). And the swimming distance in the skilled reaching group was shorter than that in the control group and running wheel group at the first and the fourth day of water maze test(P<0.05). The times of crossing the platform in the tMCAO groups were less than that in the sham group(P<0.05). The crossing times in the skilled reaching group and the running wheel group were more than that in the control group(P<0.05). In addition, the times in the skilled reaching group was higher than that in the running wheel group(P<0.05). Conclusion: Exercise training can improve cognitive function of tMCAO rats at recovery stage. In addition, skilled reaching training is superior to running wheel exercise in promoting cognitive rehabilitation.
Keywords:exercise training  transient middle cerebral artery occlusion  recovery stage  cognitive function
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