设为首页
加入收藏
联系我们
Email-Alert
 

    首页 | 杂志介绍 | 编委成员 | 审稿专家名录 | 投稿指南 | 订阅指南 | 过刊浏览 | 论著模板 | 综述模板 | 帮助

 
李 冰,励建安,朱 杰,刘守国.兔乙醇胫神经干阻滞的量效关系研究[J].中国康复医学杂志,2011,26(7):609~614
兔乙醇胫神经干阻滞的量效关系研究    点此下载全文
李 冰  励建安  朱 杰  刘守国
南京医科大学第一附属医院康复科,南京,210009
基金项目:
DOI:
摘要点击次数: 1388
全文下载次数: 1499
摘要:
      摘要 目的:明确兔乙醇胫神经阻滞的量效关系。 方法:新西兰兔24只,胫神经44条,外周神经电刺激器引导下,行胫神经无水乙醇阻滞。按注射容量分为4组:0.1ml、0.3ml、0.5ml和1.0ml。分别于阻滞前和阻滞后第1、2、4、7天及2、3、4、5、6、7、8周,记录腓肠肌复合肌肉动作电位(CMAP);实验终止时,取胫神经和注射部位肌肉行HE染色,观察组织学损害。 结果:小容量0.1ml组CMAP波幅在第1周有所恢复,但第2周作用基本消失(P>0.05),而0.3ml组的作用持续到第8周(P<0.05);大容量组(0.5ml和1.0ml)CMAP波幅降低更明显(P<0.05),但并发症也显著增加。大部分动物(9/15)因并发症死亡,故实验在第4周终止。前4周CMAP波幅降低,除0.3ml与0.5ml组间差异不显著(P>0.05),其他各组间差异显著(P<0.05);组织学示各组出现不同程度神经轴索变性;0.5ml和1.0ml组肌肉局灶性结缔组织增生。 结论:兔乙醇胫神经干阻滞的理想有效安全容量是0.3ml/点。
关键词:量效关系  神经溶解技术  酒精  胫神经  复合肌肉动作电位
The research of dose-response relationship following alcohol-induced rabbits′ tibial nerve block    Download Fulltext
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029
Fund Project:
Abstract:
      Abstract Objective: To verify the dose-response relationship in alcohol-induced rabbits′ tibial nerve block. Method: Twenty-four New Zealand white rabbits were randomly assigned to four groups based on alcohol volume (0.1ml、0.3ml、0.5ml、1.0ml). All tibial nerves were successfully located with a nerve electrical stimulator. Compound muscle action potential (CMAP) was measured on the skin surface of gastrocnemius muscle belly preintervention and at days 1, 2, 4, 7 and weeks 2, 3, 4, 5, 6, 7, 8 postblock. Histologic studies were performed to evaluate the destruction of tibial nerves and muscles. Result: In four groups, CMAP amplitude showed reduction 1 day after nerve block. In group 0.1ml, CMAP amplitude showed the smallest reduction at 1 day and recovered in 1 week after block, but the block effect disappeared at 2 week after block(P>0.05). In group 0.3ml, the block effect last 8 weeks. In groups 0.5ml and 1.0ml, CMAP amplitudes showed maximal reduction 1 day after block 4 weeks and no increase later. There was no statistically difference between groups 0.3ml and 0.5ml (P<0.05). Axonal degeneration was evident within the tibial nerve among all groups. Muscle desmoplasia was noted within the groups of 0.5ml and 1.0ml. Conclusion: The most effective and safest volume is 0.3ml for alcohol induced rabbits′ tibial nerve block.
Keywords:dose-response relationship  neurolysis  alcohol  tibial nerve  compound muscle action potential
查看全文  查看/发表评论  下载PDF阅读器

您是本站第 23505541 位访问者

版权所有:中国康复医学会
主管单位:国家卫生健康委员会 主办单位:中国康复医学会
地址:北京市朝阳区樱花园东街,中日友好医院内   邮政编码:100029   电话:010-64218095   

本系统由北京勤云科技发展有限公司设计 京ICP备18060696号-2