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吴永涛,刘宏亮,陈兴书,蔡其燕,姚忠祥.大麻素受体在成年大鼠脑组织中的分布特点[J].中国康复医学杂志,2009,24(3):197~199
大麻素受体在成年大鼠脑组织中的分布特点    点此下载全文
吴永涛  刘宏亮  陈兴书  蔡其燕  姚忠祥
第三军医大学西南医院康复科,重庆,400038
基金项目:国家自然科学基金资助项目(30572364)
DOI:
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摘要:
      目的:研究大麻素CB1、CB2受体在成年大鼠脑组织的分布特点和规律,为进一步研究其功能打下基础。方法:用兔抗鼠CB1、CB2受体特异性抗体免疫组化染色,检测大鼠脑组织主要部位两种受体的表达分布情况。结果:CB1受体阳性细胞在脑组织有广泛大量的分布,大脑皮质、胼胝体、海马、基底核区及小脑浦肯野细胞层、脑桥等区域均有较明显表达。CB2受体阳性细胞的数量及分布部位与CB1受体表达基本一致,少数区域如胼胝体、小脑白质阳性细胞数相差较大,CB2受体明显多于CB1受体的表达。结论:大麻素CB1、CB2受体在成年大鼠脑组织均广泛分布,并在多数部位表达情况一致,少数部位存在表达程度差异,提示其在神经系统中参与了某些生理及病理作用。 关键词 CB1受体;CB2受体;大麻素;脑组织;大鼠
关键词:CB1受体  CB2受体  大麻素  脑组织  大鼠
Department of Rehabilitation, Southwest Hospital, Chongqing, 400038    Download Fulltext
Department of Rehabilitation, Southwest Hospital, Chongqing, 400038
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Abstract:
      Objective: To examine the expressions of cannabinoid receptor CB1、CB2 -positive cells in adult rat brain. Method: Immunohistochemical method was used to demonstrate the expressions of CB1、CB2 -positive cells in different regions of adult rat′s brain. Result: CB1 receptors widely expressed in adult rat′s brain, and concentrated in cortex, callosum, hippocampus, basal nucleus,cerebellum Purkinje layer and pons cerebelli. Distribution of CB2 receptors were similar to that of CB1 receptors in most cases, the quantitive differences existed in the regions of callosum and cerebellum. Expressions of CB2 receptors were more than that of CB1 receptors. Conclusion: Receptors of CB1 and CB2 both were widely expressed in adult rat′s brain. The expression regions were similar, while in some regions the expression level were different. It might indicate that CB1 and CB2 receptors played some roles in physiological and pathological process in nervous system.
Keywords:CB1 receptor  CB2 receptor  Cannabinoid  brain  rat
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